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KMID : 0378019690120080057
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New Medical Journal
1969 Volume.12 No. 8 p.57 ~ p.71
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Experimental Study on the Effect of Female Sex Ilormone on the Thyroid Function
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Abstract
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This study was designed to test thyroid function of adult female rats in 26 control group of regular sex cycle, and in 48 castrated group. Thyroid responsiveness to the stimulation with female sex hormone was also evaluated in 36 castrated group, and in 12 noncastrated group with their suppressed midbrain. Sex cycle was determined by vaginal smear and the suppression of midbrain was attained by administration of
chloropromazine and phenobarbital. The following parameters were tested: I131 uptake, conversion ratio of serum I131 to PBI, and histological examination of the thyroid gland. The following results were obtained
1) In the control group, I131 uptake reached its maxium value (29. 0±0. 95%) in estrus, but minimum (23.0±0.74%) in diestrus. Conversion ratio and thyroid histology showed no cyclic change.
2) In the castrated group, both I131 uptake and conversion ratio decreased from the 14th castrated day. The former continued to decrease reaching its minimum value on the 35th or 42nd day, while the latter increased from the 35th day reaching its maximum value on the 42nd or 60th day. Thyroid histology began to show hypoplastic patterns from the 14th castrated day.
3) In the castrated group, with administration of female sex hormone
a. with estrogen only, 1131 uptake increased without changes in conversion ratio or thyroid histology.
b. with progesterone only, no changes in three parameters
c. with conbination of estrogen and progesterone, 1131 uptake and conversion ratio increased without histological changes.
4) In the non-castrated group with suppressed midbrain, estrogen only was given. I1U1 uptake decreased within the value of control group, while conversion ratio and thyroid histology were unchanged.
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KEYWORD
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